The creators of the show, Matt Stone and Trey Parker, based the Stan Marsh and Kyle Brosfloski characters after themselves (Stan being Parker and Kyle being Stone.) The Eric Cartman character was partly based on Archie Bunker.

Dr. Mephisto is based on Marlon Brando in The Island of Dr. Moreau (1996).

Every time Chef talks to the kids he says "children" even if its only one kid.

Trey Parker and Matt Stone are big Star Trek fans and try to slip at least one Star Trek reference into each episode.

Liane was the name of Trey Parker's ex-fiance who left him a month before their wedding, which explains a lot of the jokes about Cartman's mom.

While an episode of The Simpsons takes several months to complete, an episode of South Park of the same length take only about a week to complete.

Mr. Mackey was based on a school counselor Trey Parker had in Jr. High school (confirmed by Trey).

At several points in the show when the demonic voices are singing, "Rectoos. Dominoos." at some points you can hear them say, "Cheesy Poofs.".

In the "That Guy Hitler" video, most of Hitler's "German" is nonsense, but his second line translates roughly as "I love your breasts, dear".

If you look carefully, you can see that the driver of Leo Dicaprio's limo is a Visitor.

Cartman thinking he's a Vietnamese prostitute is based on the Vietnamese prostitute in Full Metal Jacket.

When Officer Barbrady goes back to school, on the alphabet chart behind Mr. Garrison, the letters are arranged to spell "Dios Mio Mataron a Kenny, bastardo", Spanish for "Oh my God they killed Kenny, you bastard."

This episode aired the day "Cartman's Mom is Still a Dirty Slut" was supposed to air. Since it was April Fools Day, the creators decided to play a prank by airing this episode. This resulted in Comedy Central getting phone calls from angry viewers who hated how they had waited four weeks for the identity of Cartman's father to be revealed only to discover that they had to wait an additional three weeks for the actual episode. Consequently, this episode was shown again on Comedy Central only twice. The second being right before the release of the movie.

The title of this episode translates from Japanese as "penis monsters". ('chinpoko' is Japanese slang for penis, 'mon' is short for monster).

Kyle does not have one single line in this episode.

The ending where Cartman tricks Scott Tenorman into eating his parents is based on the ending of William Shakespeare's "Titus Andronicus".

The whole fight is done the same way as the fight in the movie, They Live.

The TV studio backgrounds are actually the military base backgrounds from "Towelie". You can tell by the maps on the walls.

When the fake Mongolians are attacking the wall with the tape recorder on the ground, the sound effects seem to be taken directly from Microsoft's Age of Empires II.

Jared Fogel actually did an interview on the "Bob and Tom" show in which he discussed this episode.