Continuity: After beating the lake monster Del Lago and going through the cutscene and chapter end, you can take the boat out on the lake. When you come up to a dock, you can bring the boat up to either side. The cutscene always shows Leon pulling the boat up to the same side of the dock, regardless of which side you chose beforehand.

Continuity: During the ingame cutscenes, Leon will always have his starting pistol equipped regardless of whether you sell it or have a different weapon equipped.

Other: Whenever Leon reloads his Shotgun, Riot Gun or Striker, he always puts in two shells, regardless of how many are actually reloaded.

Continuity: After Leon beats Bitores Mendez and takes his fake eye, you will notice if you look closely at his corpse that his fake eye is still in his head.

Plot hole: Just before the boss battle with 'it' in the hanging cages, you first come across the monster on a ledge, and then you're instantly transported to the suspended hanging cages, with absolutely no indication of how.

Factual error: In spite of its description calling it "one of a kind," there are two Elegant Headdresses in the game.

Other: After fighting the lake monster, if Leon is wearing his police uniform (unlocked after beating the game), in the next cutscene he has a nightmare about the Las Plagas in his body. He looks down at his arm (which is now infected with the Las Plagas) and screams, but since the jacket is covering his arm, he would not have been able to see it.