Other: In 'Keep your Friends Close,' in the first cutscene, Tommy says put 20 million in cases, but the subtitles say three.
Continuity: On the final mission, once you kill the final boss, the gun you will be holding in the cut scene is a M4, even if you used a different gun.
Factual error: During his interview on K-Chat, B.J. Smith says "Like the song says, 'don't call it a comeback.'" The song he's quoting is "Mama Said Knock You Out" by L.L. Cool J, which wasn't released until four years after the game takes place.
Continuity: When you first visit the yacht owned by Mercedes' father, two of the guests there are Pastor Richards and B.J Smith. Yet if you listen to "K Chat" or "VCPR" after you leave, they are both being interviewed on the radio at the same time.