Continuity: While Stu and Chuck are in the park playing frisbee, over Stu's right shoulder a woman carrying a soda sits down at a picnic table twice.
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Trivia
In the scene where Chuck and Stu are playing frisbee, the hat that Chuck is wearing is the Super Club hat from Dane Cook's previous film, Employee of the Month. See more...
Continuity: During the scene when Charlie is playing the Xbox 360 his friend comes in and he puts down the Xbox controller, but it changes position between shots.
Deliberate "mistake": In Antarctica when Charlie and Cam kiss, their tongues become froze together but this is impossible as it would take a freezing object for this to work.
Revealing: When Jessica Alba's character is in the dentists room with the chipped tooth, its very obvious shes wearing a set of false teeth over her teeth.